Regenerative
TB-500
Overview
TB-500 is a synthetic fragment corresponding to the active region of Thymosin beta-4, a 43-amino-acid polypeptide that is the primary G-actin-sequestering peptide in cells. It is studied in tissue-repair, angiogenesis, and cell-migration research.
Mechanism
A seven-amino-acid actin-binding motif is essential for the angiogenic activity of Thymosin beta-4. Research reports promotion of endothelial cell migration, tubule formation, and accelerated re-epithelialization in dermal wound-healing assays.
Research Areas
- Actin regulation and cell migration
- Angiogenesis and endothelial tubule formation
- Wound-healing and re-epithelialization models
Handling & Storage
Lyophilized; store refrigerated. Reconstitute with bacteriostatic water for research use.
References
- 1.Malinda KM, et al. Thymosin beta4 accelerates wound healing. Journal of Investigative Dermatology (PubMed 10469335), 1999.
- 2.Philp D, et al. The actin binding site on thymosin beta4 promotes angiogenesis. FASEB Journal (PubMed 14500546), 2003.