Semax

Overview

Semax is a synthetic heptapeptide analogue of the ACTH(4-10) fragment, developed in Russia and studied for nootropic and neuroprotective research applications. A C-terminal Pro-Gly-Pro extension increases its metabolic stability.

Mechanism

Semax administration produces rapid and specific changes in BDNF and NGF expression in the rat hippocampus and frontal cortex, including hippocampal BDNF-mRNA increase and TrkB phosphorylation following a single intranasal dose.

Research Areas

• BDNF / NGF expression dynamics
• TrkB signaling in hippocampus and cortex
• Neuroprotection in focal-ischemia models

Handling & Storage

Lyophilized; store refrigerated. Reconstitute with bacteriostatic water for research use.

References

1. 1.Dolotov OV, et al. Semax, an analogue of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Research (PubMed 16635254), 2006.
2. 2.Shadrina M, et al. Comparison of the temporary dynamics of NGF and BDNF gene expression in rat hippocampus, frontal cortex, and retina under Semax action. PubMed 19662538, 2010.