Neurological
Selank
Overview
Selank is a synthetic heptapeptide analogue of the immunomodulatory peptide tuftsin, developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. It is studied primarily for anxiolytic and cognitive research applications.
Mechanism
Selank combines the tuftsin fragment Thr-Lys-Pro-Arg with a Pro-Gly-Pro extension that confers metabolic stability. Research links its effects to modulation of GABAergic neurotransmission and brain serotonin metabolism, without the sedation profile of benzodiazepines.
Research Areas
- GABAergic neurotransmission gene expression
- Serotonin-metabolism modulation
- Anxiolytic and neuroprotective models
Handling & Storage
Lyophilized; store refrigerated. Reconstitute with bacteriostatic water for research use.
References
- 1.Kolik LG, et al. Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats. Bulletin of Experimental Biology and Medicine (PubMed 36322304), 2022.
- 2.Volkova A, et al. GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission. Frontiers in Pharmacology, 2017.