Metabolic
MOTS-c
Overview
MOTS-c is a mitochondrial-derived peptide encoded within the mitochondrial genome, studied for its regulatory effects on metabolic homeostasis. Research characterizes it as a signaling peptide that influences insulin sensitivity, glucose handling, and the cellular response to metabolic stress.
Mechanism
MOTS-c acts largely through activation of AMP-activated protein kinase (AMPK). Under metabolic stress it translocates to the nucleus and regulates nuclear gene expression in an AMPK-dependent manner, and promotes glucose uptake via the AMPK pathway.
Research Areas
- AMPK-pathway activation and metabolic signaling
- Nuclear translocation and stress-responsive gene expression
- Insulin sensitivity and glucose-handling models
Handling & Storage
Lyophilized; store refrigerated. Reconstitute with bacteriostatic water for research use.
References
- 1.Kim KH, et al. The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress. Cell Metabolism (PubMed 29983246), 2018.
- 2.Wan W, et al. MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation. Frontiers in Endocrinology (PMC9905433), 2023.