Cellular Health
Glutathione
Overview
Glutathione (GSH) is an endogenous tripeptide (glutamate-cysteine-glycine) and one of the most abundant low-molecular-weight non-protein thiols in cells. It is a central intracellular antioxidant studied in oxidative-stress and detoxification research.
Mechanism
Glutathione modulates physiological levels of reactive oxygen species and participates in the cell's oxidative-stress response, plays a key role in detoxification of xenobiotic compounds, and serves as a substrate for glutathione peroxidase in neutralizing free radicals.
Research Areas
- Reactive-oxygen-species modulation
- Xenobiotic detoxification pathways
- Oxidative-stress research in neurodegeneration models
Handling & Storage
Lyophilized; store refrigerated and protected from light. Reconstitute with bacteriostatic water for research use.
References
- 1.Bains JS, Shaw CA. Glutathione, oxidative stress and neurodegeneration. European Journal of Biochemistry (PubMed 10931172), 2000.
- 2.Forman HJ, et al. The antioxidant glutathione. Vitamins and Hormones (PubMed 36707132), 2023.