Cellular Health
Epithalon
Overview
Epithalon (Ala-Glu-Asp-Gly, AEDG) is a synthetic tetrapeptide derived from the pineal peptide epithalamin, developed by Vladimir Khavinson's laboratory at the St. Petersburg Institute of Bioregulation and Gerontology. It is the most extensively studied peptide targeting telomere biology.
Mechanism
In human somatic cell cultures, epithalon has been reported to induce expression of the telomerase catalytic subunit (hTERT), increase telomerase activity, and produce measurable telomere elongation. Research also describes effects on pineal function and antioxidant-enzyme activity.
Research Areas
- Telomerase (hTERT) induction and telomere elongation
- Pineal-gland function and gene-expression research
- Antioxidant-enzyme activity in aging models
Handling & Storage
Lyophilized; store refrigerated. Reconstitute with bacteriostatic water for research use.
References
- 1.Khavinson VK, et al. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bulletin of Experimental Biology and Medicine (PubMed 14625604), 2003.
- 2.Ilina A, et al. AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism. Molecules, 2020.