Neurological
DSIP
Overview
DSIP (delta sleep-inducing peptide) is a naturally occurring nonapeptide isolated and synthesized between 1970 and 1977. It is studied for its effects on sleep architecture and stress-axis regulation, though its precise mechanism remains an open research question.
Mechanism
Human studies report that DSIP increases total sleep time and sleep quality by sustaining natural sleep functions rather than producing classical pharmacological sedation. Plasma DSIP shows diurnal rhythmicity correlating with body temperature and sleep stages.
Research Areas
- Slow-wave sleep and sleep-architecture research
- Diurnal-rhythm and stress-axis correlation
- Non-sedative sleep-support models
Handling & Storage
Lyophilized; store refrigerated. Reconstitute with bacteriostatic water for research use.
References
- 1.Schneider-Helmert D, Schoenenberger GA. The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep. Experientia (PubMed 7028502), 1981.
- 2.Kovalzon VM, Strekalova TV. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. Journal of Neurochemistry (PubMed 16539679), 2006.