BPC-157
Overview
BPC-157 is a stable pentadecapeptide derived from a sequence in human gastric juice. Across numerous animal studies it has been reported to promote healing of skin, muscle, bone, ligament, tendon, and gastrointestinal tissue. Current evidence is preclinical (predominantly rodent models); there are no established human efficacy trials.
Mechanism
Experimental studies attribute BPC-157's tissue-repair activity to promotion of angiogenesis, collagen synthesis, and fibroblast activity, alongside modulation of nitric oxide pathways. In tendon fibroblasts, BPC-157 has been shown to upregulate growth hormone receptor expression at both mRNA and protein levels and to accelerate the outgrowth of tendon explants in vitro.
Research Areas
- Tendon, ligament, and myotendinous-junction repair in rodent models
- Angiogenesis and collagen-synthesis signaling
- Growth hormone receptor upregulation in tendon fibroblasts
Handling & Storage
Lyophilized; store refrigerated. Reconstitute with bacteriostatic water for research use.
References
- 1.Chang CH, et al. Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts. Molecules (PubMed 25415472), 2014.
- 2.Chang CH, et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. Journal of Applied Physiology, 2011.
- 3.Staresinic M, et al. Stable Gastric Pentadecapeptide BPC 157 as a Therapy for the Disable Myotendinous Junctions in Rats. Biomedicines (PubMed 34829776), 2021.